Journal of pediatric hematology/oncology
-
J. Pediatr. Hematol. Oncol. · Mar 1998
In vitro antitumor activity of rebeccamycin analog (NSC# 655649) against pediatric solid tumors.
This study determined the in vitro antitumor activity of a rebeccamycin analog (NSC# 655649) using tetrazolium/formazan (MTT) and clonogenic assays against established pediatric cell lines and solid tumor specimens obtained from children. ⋯ NSC# 655649 appears to have broad antitumor activity in vitro against pediatric malignancies at drug concentrations achieved during adult phase I clinical trials. These studies support the further development of NSC# 655649 for solid tumors in children.
-
J. Pediatr. Hematol. Oncol. · Mar 1998
Case ReportsPhenytoin-induced thrombocytopenia treated with intravenous immune globulin.
To describe the use of intravenous immune globulin (IVIG) in an 8-year-old girl with phenytoin-induced thrombocytopenia and leukopenia. ⋯ Phenytoin hypersensitivity can present with thrombocytopenia and leukopenia. Treatment with IVIG was associated with a rapid rise in the platelet count in the patient in this report. IVIG should be considered for patients with phenytoin-induced thrombocytopenia.