Journal of pediatric hematology/oncology
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J. Pediatr. Hematol. Oncol. · Jan 2003
Multicenter Study Clinical TrialRecombinant tissue plasminogen activator (alteplase) for restoration of function to occluded central venous catheters in pediatric patients.
To evaluate the safety and efficacy of alteplase for restoring function to occluded central venous catheters in a pediatric population. ⋯ An alteplase regimen of up to two 2-mg doses is safe and effective for restoration of function to occluded central venous catheters in a pediatric population.
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J. Pediatr. Hematol. Oncol. · Jan 2003
Case ReportsPolyclonal proliferation of lymphocytes containing the epstein-barr virus genome in a patient dying of myocarditis in chronic active Epstein-Barr virus infection.
An 11-year-old boy had intermittent fever and hepatosplenomegaly. The diagnosis of chronic active Epstein-Barr virus (EBV) infection was established from an abnormal pattern of anti-EBV antibody; EBV was detected in bone marrow cells. Immunochemotherapy alleviated the patient's symptoms. ⋯ Autopsy findings demonstrated that myocarditis resulted from infiltrating T lymphocytes with the EBV genome and a benign histologic appearance. A clonality study of T lymphocytes indicated no such evidence of monoclonality. EBV-infected T cells play an important role in the pathogenesis of myocarditis in chronic active EBV infection.
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J. Pediatr. Hematol. Oncol. · Jan 2003
Comparative StudyWhole blood international normalization ratio measurements in children using near-patient monitors.
To report a comparison of international normalization ratio (INR) measurements on four near-patient (point-of-care or bedside) whole blood INR monitors in children. ⋯ Near-patient testing whole blood INR monitors offer acceptably accurate and precise measurements. Values obtained on near-patient monitors may vary considerably from the reference method, and data obtained should serve as a supplement to, but not a replacement for, routine clinical laboratory measurements.