Journal of pediatric hematology/oncology
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J. Pediatr. Hematol. Oncol. · Nov 2010
Review Case ReportsTreatment of Gorham-Stout disease with zoledronic acid and interferon-α: a case report and literature review.
Gorham-Stout disease is a rare disease characterized by osteolysis, angiomatosis, and soft-tissue swelling. It is a diagnosis of exclusion and has an unknown etiology. ⋯ There is no standard of treatment. We report a case of a 16-year-old female with Gorham-Stout disease and recurrent pleural effusions who was successfully treated with concurrent zoledronic acid and peg-interferon α-2b.
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J. Pediatr. Hematol. Oncol. · Nov 2010
Early changes in SOFA score as a prognostic factor in pediatric oncology patients requiring mechanical ventilatory support.
To evaluate whether changes in outcome prediction scores during the first 72 hours after admission to a pediatric intensive care unit (PICU) are more predictive of outcome than single assessments at admission in pediatric oncology patients requiring mechanical ventilatory support for more than 3 days. ⋯ Serial evaluation of SOFA score during the first few days after PICU admission was a good predictor of prognosis in pediatric oncology patients mechanically ventilated over 3 days. Independent of initial SOFA score, Δ-SOFA score during the first 72 hours closely correlated with outcome. Early changes in respiratory parameters, such as P/F ratio, OI, and VI, may also provide valuable prognostic information in such patients.