Journal of pediatric hematology/oncology
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J. Pediatr. Hematol. Oncol. · Jul 2013
Historical ArticlePredictors for bacteremia in febrile sickle cell disease children in the post-7-valent pneumococcal conjugate vaccine era.
The objective of this study was to determine the incidence of bacteremia in febrile sickle cell disease (SCD) children before and after the 7-valent pneumococcal vaccine (PCV7), and to determine clinical factors associated with bacteremia following PCV7. ⋯ In febrile SCD children, the incidence of general bacteremia decreased over time. No decrease in pneumococcal bacteremia was found. The presence of a central venous line, absolute band count, clinical appearance, and age may help predict bacteremia in this population.
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J. Pediatr. Hematol. Oncol. · Jul 2013
Clinical TrialProspective surveillance study of blood stream infections associated with central venous access devices (port-type) in children with acute leukemia: an intervention program.
The use of intensive chemotherapy and central devices has improved patients survival, but it is associated with catheter-related blood-stream infections (CRBSI). An educational program was instituted for preventing CRBSI occurrence in acute leukemia pediatric patients having totally implanted central devices. The Centers of Disease Control and Prevention criteria were used as definition for CRBSI. ⋯ Six patients needed a central venous access device replacement. Our intervention program was successful to decrease the CRBSI rates and its intensification allowed a further decrease, approaching reported rates in this setting. Severe neutropenia at the time of central venous access device insertion was related to CRBSI occurrence and recurrence.