European journal of neurology : the official journal of the European Federation of Neurological Societies
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Randomized Controlled Trial Multicenter Study
A double-blind, randomized trial of duloxetine versus placebo in the management of chronic low back pain.
Duloxetine has demonstrated analgesic effect in chronic pain states. This study assesses the efficacy of duloxetine in chronic low back pain (CLBP). ⋯ Duloxetine was superior to placebo on the primary objective from weeks 3-11, but superiority was not maintained at end-point. Duloxetine was superior to placebo on many secondary measures, and was well-tolerated.