European journal of neurology : the official journal of the European Federation of Neurological Societies
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Ultrasound-guided lumbar puncture for nusinersen administration in spinal muscular atrophy patients.
The purpose was to report the results of ultrasound-guided lumbar puncture for the administration of nusinersen in spinal muscular atrophy (SMA) patients with complex spines. ⋯ The ultrasound-guided lumbar puncture, following an interlaminar parasagittal approach, is a safe and effective approach for intrathecal treatment with nusinersen in children, adolescents and carefully selected adult SMA patients with complex spines and could be considered the first option in them.