The journal of alternative and complementary medicine : research on paradigm, practice, and policy
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J Altern Complement Med · Aug 2019
Randomized Controlled Trial Multicenter StudyThe Efficacy and Safety of Xinmailong Injection in Patients with Chronic Heart Failure: A Multicenter Randomized Double-Blind Placebo-Controlled Trial.
Objectives: Chronic heart failure (CHF) is a chronic and progressive disease with high incidence. The aim of this study was to evaluate the effectiveness and safety of Xinmailong injection (XI) on CHF patients with B-type natriuretic peptide (BNP) ≥200 ng/mL and left ventricular ejection fraction (LVEF) of ≤45%. Trial design: This is a randomized double-blind placebo-controlled trial. ⋯ No deaths occurred in the course of this study. The number of adverse events between the two groups was not statistically different (p > 0.05). Conclusions: XI can alleviate the symptoms, improve heart function, and exercise tolerance in patients with CHF and is safe to use.