Inflammation research : official journal of the European Histamine Research Society ... [et al.]
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To investigate the effect of FR167653, a dual inhibitor of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1), on Bacillus Calmétte-Guérin (BCG) plus lipopolysaccharide (LPS) induced-liver injury and its mechanisms. ⋯ TNF-alpha and IL-1 released from activated KCs were involved in BCG plus LPS induced liver injury. FR167653 significantly attenuated hepatocyte injury via inhibition of TNF-alpha and IL-1 released from activated KCs.