Inflammation research : official journal of the European Histamine Research Society ... [et al.]
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The present study defines the expression of Toll-like Receptor 2 (TLR2), and the modulatory role of Glycogen synthase kinase (GSK)-3beta inhibitor on TLR2/Nuclear Factor-kappa B (NF-kappaB) signaling following myocardial ischemia-reperfusion (MI-R) injury in rats. ⋯ Our results demonstrate that TLR2 and its signaling components are activated by MI-R. TDZD-8 administration attenuates TLR2/NF-kappaB signaling, suggesting a possible mechanism whereby GSK-3beta inhibition improves the outcome of MI-R.