Inflammatory bowel diseases
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Inflamm. Bowel Dis. · Apr 2011
Comparative StudyAngiogenin, angiopoietin-1, angiopoietin-2, and endostatin serum levels in inflammatory bowel disease.
Angiogenesis is a complex process, involving a great number of mediators. It is implicated in the pathogenesis of numerous diseases, holding a critical role in inflammatory bowel disease (IBD). The objective of this study was to assess serum levels of angiogenin, angiopoietin-1, angiopoietin-2, and endostatin in IBD patients. ⋯ Elevated serum angiogenin and angiopoietin-2 levels and lower serum angiopoietin-1 levels were shown in IBD patients, as well as a different pattern of angiogenic factor alterations related to location, treatment, smoking habits and gender.