Inflammatory bowel diseases
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Inflamm. Bowel Dis. · Dec 2012
Review Meta AnalysisAnti-tumor necrosis factor and postoperative complications in Crohn's disease: systematic review and meta-analysis.
Anti-tumor necrosis factor (TNF) antibodies are efficacious in patients with Crohn's disease (CD) but the influence of these medications on surgical outcomes in CD patients has been frequently debated. The aim was to evaluate the impact of preoperative treatment with anti-TNF antibodies on postoperative complications in CD patients undergoing abdominal surgery. ⋯ Preoperative infliximab treatment is associated with an increased risk of postoperative infectious complications, mostly nonlocal. A trend toward an increased risk of noninfectious and overall complications was also observed.
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Inflamm. Bowel Dis. · Dec 2012
Fecal calprotectin is a surrogate marker for endoscopic lesions in inflammatory bowel disease.
Fecal calprotectin is a marker of inflammation in inflammatory bowel disease (IBD). Since mucosal healing has become a goal of treatment in IBD we examined how reliably calprotectin levels reflect mucosal disease activity. ⋯ Fecal calprotectin levels correlate significantly with endoscopic disease activity in IBD. The test appears useful in clinical practice for assessment of endoscopic activity and remission.