Inflammatory bowel diseases
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Inflamm. Bowel Dis. · Sep 2016
Multicenter StudyMulti-Center Experience of Vedolizumab Effectiveness in Pediatric Inflammatory Bowel Disease.
Though vedolizumab has received regulatory approval for the treatment of Crohn's disease (CD) and ulcerative colitis (UC) in adults, there is increasing off-label use in children. ⋯ Our results suggest that vedolizumab is efficacious and safe in pediatric IBD patients, with UC patients experiencing earlier and higher rates of remission than CD patients. Anti-TNF-naive patients experienced higher remission rates than those with anti-TNF exposure. Controlled clinical trial data are needed to confirm these observations.