Neurobiology of learning and memory
-
Neurobiol Learn Mem · Jan 1998
Comparative StudyFurther support for nitric oxide-dependent memory processing in the day-old chick.
There is considerable evidence that nitric oxide activity is essential for memory formation, particularly from studies using inhibitors of nitric oxide synthase. The particular stage of memory formation requiring nitric oxide activity has not, however, been systematically investigated. ⋯ This effect was replicated with a second inhibitor, l-NG-nitroarginine (1 mM), and counteracted by the NO donor, sodium nitroprusside (150 microM). These findings provide covergent evidence that nitric oxide activity plays a critical role in the consolidation of memory in the day-old chick.