The international journal of biochemistry & cell biology
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Int. J. Biochem. Cell Biol. · Apr 2010
ReviewThe role of toll-like receptors in chronic inflammation.
The role of Toll-like receptors (TLRs) in innate immunity and their ability to recognise microbial products has been well characterised. TLRs are also able to recognise endogenous molecules which are released upon cell damage and necrosis and have been shown to be present in numerous autoimmune diseases. ⋯ Although at present their involvement is not comprehensively defined. However, future therapies targeting individual TLRs or their signalling transducers may provide a more specific way of treating inflammatory diseases without global suppression of the immune system.