Multiple sclerosis : clinical and laboratory research
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Cognitive impairment affects 40%-68% of relapsing-remitting multiple sclerosis (RRMS) patients. Gray matter (GM) demyelination is complicit in cognitive impairment, yet cortical lesions are challenging to image clinically. We wanted to determine whether cortical cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) differences exist between cognitively impaired (CI) and unimpaired (NI) RRMS. ⋯ Significant cortical CBF and CBV reduction was present in CI compared to NI in the absence of structural differences.
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A functional cortico-subcortical disconnection has been recognized in fatigued multiple sclerosis (MS) patients. Normal appearing white matter (NAWM) damage might contribute to the abovementioned disconnectivity. ⋯ Fatigue is associated to a widespread microstructural NAWM damage, particularly in associative tracts connected to frontal lobes.