Multiple sclerosis : clinical and laboratory research
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Corrigendum to 25-hydroxyvitamin D in cerebrospinal fluid during relapse and remission of multiple sclerosis by Trygve Holmøy, Stine Marit Moen, Thomas A Gundersen, Michael F Holick, Enrico Fainardi, Massimiliano Castellazzi and Ilaria Casetta. 15(11) 1280-1285 [DOI: 10.1177/1352458509107008].
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Corrigendum to Munger, KL and Ascherio A. (2011). Prevention and treatment of MS: studying the effects of vitamin D Multiple Sclerosis Journal 17(12) 1405-1411. [DOI:10.1177/1352458511425366].
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Histopathological studies have revealed four different immunopathological patterns of lesion pathology in early multiple sclerosis (MS). Pattern II MS is characterised by immunoglobulin and complement deposition in addition to T-cell and macrophage infiltration and is more likely to respond to plasma exchange therapy, suggesting a contribution of autoantibodies. ⋯ This is the largest study on established anti-neural antibodies performed in MS so far. MOG-IgG may play a role in a small percentage of patients diagnosed with pattern II MS.
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White matter lesions are frequently detected using brain magnetic resonance imaging (MRI) performed for various indications. Most are microangiopathic, but demyelination, including multiple sclerosis (MS), is an important cause; conventional MRI cannot always distinguish between these pathologies. The proportion of lesions with a central vein on 7-T T2*-weighted MRI prospectively distinguishes demyelination from microangiopathic lesions. ⋯ 3-T T2*-weighted brain MRI distinguishes perivenous MS lesions from microangiopathic lesions. Clinical application of this technique could supplement existing diagnostic algorithms.