Investigative radiology
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Investigative radiology · Jan 2010
Minimization of MR contrast weightings for the comprehensive evaluation of carotid atherosclerotic disease.
Multicontrast, high-resolution carotid magnetic resonance imaging (MRI) has been validated with histology to quantify atherosclerotic plaque morphology and composition. For evaluating the lipid-rich necrotic core (LRNC) and fibrous cap, both of which are key elements in determining plaque stability, the combined pre- and postcontrast T1-weighted (T1W) sequences have been recently shown to have a higher reproducibility than other contrast weightings. In this study, we sought to determine whether contrast weightings beyond T1W (pre- and postcontrast) are necessary for comprehensive, quantitative, carotid plaque interpretation. ⋯ Comprehensive, quantitative carotid plaque interpretation can be performed with T1W, CE-T1W, and TOF sequences. Elimination of PD and T2W sequences from the carotid MRI protocol may result in a substantial reduction in scan time. The ability to perform plaque interpretation on images acquired within a clinically acceptable scan time may broaden the research utility of carotid MRI and increase translatability to clinical applications.