Investigative radiology
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Investigative radiology · Dec 2010
Carotid plaques in transient ischemic attack and stroke patients: one-year follow-up study by magnetic resonance imaging.
To investigate the natural course of carotid plaque progression in transient ischemic attack/stroke patients by using serial multisequence magnetic resonance imaging (MRI). ⋯ In symptomatic patients with an ipsilateral carotid plaque causing <70% stenosis, we found evidence for inward plaque remodeling over a 1-year period. Overall, the presence/absence of IPH, a LRNC, and FC status did not change over 1 year.
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Investigative radiology · Dec 2010
Comparative StudyQuantitative analysis of adipose tissue in single transverse slices for estimation of volumes of relevant fat tissue compartments: a study in a large cohort of subjects at risk for type 2 diabetes by MRI with comparison to anthropometric data.
Aim of the study was to assess the potential value of cross-sectional adipose tissue evaluation in well defined single transverse slices for estimation of volumes of metabolically important adipose tissue compartments as visceral adipose tissue (VAT), nonvisceral adipose tissue (NVAT), and total body adipose tissue (TAT). In addition, validity of easily accessible anthropometric indices (waist-to-hip-ratio [WHR] and body mass index [BMI]) for prediction of volumes of those adipose tissue compartments were validated and compared. ⋯ Axial MRI at the umbilical level allowed for a fast and reliable estimation, especially for VAT and TAT in a collective at risk for type 2 diabetes. WHR and BMI were found clearly worse in prediction of VAT volumes compared with single slice evaluation at the umbilical level.
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Investigative radiology · Dec 2010
Biopsy targeting gliomas: do functional imaging techniques identify similar target areas?
Because of the heterogeneous nature of glioma, biopsies performed should be targeted at the most anaplastic region. Several functional magnetic resonance imaging (MRI) or positron emission tomography (PET) techniques have been proposed for identifying the most anaplastic tumor area. However, it is unclear whether the recommended biopsy targets based on these various functional imaging modalities correspond with each other. Thus, the purpose was to evaluate whether they identify similar target areas. ⋯ Both imaging techniques that depict microcirculation and techniques that visualize proliferation identify similar target areas.
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Investigative radiology · Dec 2010
Comparative StudyEvaluation of gadodiamide versus gadobutrol for contrast-enhanced MR imaging in a rat brain glioma model at 1.5 and 3 T.
To compare equivalently-dosed (0.1 mmol/kg) gadobutrol (Gadovist) and gadodiamide (Omniscan) in a rat brain glioma model with respect to lesion signal-to-noise (SNR), contrast-to-noise (CNR), and contrast enhancement (CE) at 1.5 and 3 T. Lesion enhancement with standard-dose gadobutrol in scans performed at 1.5 T was also compared with that of half-dose gadobutrol in scans performed at 3 T. ⋯ Gadobutrol (Gadovist) demonstrates superior lesion enhancement to equivalently-dosed gadodiamide (Omniscan) in the rat brain glioma model. These results are complemented by the improved observed and theoretical safety profile of the first agent, in particular with regard to nephrogenic systemic fibrosis. The ability to image with half-dose gadobutrol at 3 T without a statistically significant decrease in lesion enhancement, compared with 1.5 T, offers an additional theoretical safety margin and potential cost-savings.