Investigative radiology
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Investigative radiology · Apr 2010
ReviewReactive oxygen species and the pathogenesis of radiocontrast-induced nephropathy.
Experimental findings in vitro and in vivo illustrate enhanced hypoxia and the formation of reactive oxygen species (ROS) within the kidney following the administration of iodinated contrast media, which may play a role in the development of contrast media-induced nephropathy. Clinical studies indeed support this possibility, suggesting a protective effect of ROS scavenging or reduced ROS formation with the administration of N-acetyl cysteine and bicarbonate infusion, respectively. ⋯ Generated during contrast-induced renal parenchymal hypoxia, ROS may exert direct tubular and vascular endothelial injury and might further intensify renal parenchymal hypoxia by virtue of endothelial dysfunction and dysregulation of tubular transport. Preventive strategies conceivably should include inhibition of ROS generation or ROS scavenging.
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Investigative radiology · Apr 2010
Reducing abdominal CT radiation dose with adaptive statistical iterative reconstruction technique.
To assess radiation dose reduction for abdominal computed tomography (CT) examinations with adaptive statistical iterative reconstruction (ASIR) technique. ⋯ ASIR technique allows radiation dose reduction for abdominal CT examinations whereas improving image noise compared with the FBP technique.