Investigative radiology
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Investigative radiology · Dec 2012
MRI assessment of hepatic iron clearance rates after USPIO administration in healthy adults.
The purpose of this study was to monitor iron clearance from the liver by means of T2 and T2* mapping after administration of an ultrasmall superparamagnetic iron oxide (USPIO) agent. ⋯ Iron deposition in the liver after a 5 mg Fe/kg dose of ferumoxytol may alter signal contrast on MR images for several months after administration. This is an important consideration in the use of USPIO agents for diagnostic purposes.