Investigative radiology
-
Investigative radiology · Feb 2014
Comparative StudyComparison of fat saturation techniques for single-shot fast spin echo sequences for 7-T body imaging.
For T2-weighted abdominal images, homogenous fat suppression (FS) is crucial for diagnosis, but inherent B0/B1 inhomogeneities at 7 T lead to inhomogeneous FS and to tissue signal loss for most techniques. Here, 4 different FS techniques for single-shot fast spin echo were compared, whereby the recently proposed time-interleaved acquisition of modes (TIAMO) was used for the imaging portion of the sequence to reduce B1 artifacts. ⋯ Of the compared techniques, the most favorable was SSGR because, here, a homogeneous FS with moderate tissue signal loss of approximately 20% was achieved with no additional preparation pulses being necessary. Using this FS technique combined with TIAMO image acquisition, delineation between fat and bright liquids in single-shot fast spin echo images, which is essential for diagnosis, is possible at 7 T.
-
Investigative radiology · Feb 2014
Diffusion-weighted magnetic resonance imaging of the pancreas: diagnostic benefit from an intravoxel incoherent motion model-based 3 b-value analysis.
The objective of this study was to evaluate the diagnostic benefit of an intravoxel incoherent motion (IVIM) model-based characterization of pancreatic masses from diffusion-weighted imaging (DWI) with 3 b values. ⋯ The determination of IVIM-based microcirculation-sensitive parameter maps from DWI with 3 b values significantly improved the discrimination of CAs from NETs, CPs, and the healthy tissue.
-
Investigative radiology · Feb 2014
Characterization of the intestinal and hepatic uptake/efflux transport of the magnetic resonance imaging contrast agent gadolinium-ethoxylbenzyl-diethylenetriamine-pentaacetic acid.
The objectives of the study were to measure the pharmacokinetics and liver enhancement of gadoxetate (gadolinium-ethoxylbenzyl-diethylenetriamine-pentaacetic acid [Gd-EOB-DTPA], Eovist, Primovist) after oral and intravenous administration in wild-type and (multidrug resistance-associated protein 2) Mrp2-deficient rats and to evaluate the in vitro transport of the contrast agent via intestinal and hepatic transporter proteins. ⋯ The nonmetabolized Gd-EOB-DTPA may have some potentials to be used as a probe-contrast agent to evaluate transporter-mediated mechanisms along the enterohepatic absorption route for drugs by functional visualization in vivo.