Investigative radiology
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Investigative radiology · Aug 2014
Assessment of combination of contrast-enhanced magnetic resonance imaging and positron emission tomography/computed tomography for evaluation of ovarian masses.
The objectives of this study were to correlate fluorodeoxyglucose uptake in ovarian masses on positron emission tomography/computed tomography (PET/CT) with pathological grades of malignancy and subtypes and to determine the appropriate approach for combining PET/CT and contrast-enhanced magnetic resonance imaging (CE-MRI) to characterize ovarian masses. ⋯ Fluorodeoxyglucose uptake in ovarian masses correlates with pathological subtypes as well as the grade of malignancy. Furthermore, the combination of CE-MRI and PET/CT is a highly accurate method for characterizing ovarian masses because PET/CT can be used as a complement to classify indeterminate lesions as malignant or not based on appropriate cutoff SUVmax for mucinous and nonmucinous tumors.
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Investigative radiology · Aug 2014
Contrast-enhanced ultrasound identifies reduced overall and regional renal perfusion during global hypoxia in piglets.
It is well known from both clinical experience and animal research that renal hypoxia may lead to temporary or permanent renal failure, the severity being dependent largely on the duration and grade of the hypoxia. The medulla is more susceptible to hypoxic injury than the cortex because approximately 90% of the renal blood flow supplies the cortex. Various methods have been applied to evaluate renal perfusion in both experimental and clinical settings, including magnetic resonance imaging, computed tomography, laser Doppler, and contrast-enhanced ultrasound (CEUS). ⋯ Global hypoxia induced changes in overall and regional renal perfusion detectable with CEUS. Cortical and medullary flows were affected differently by hypoxia; a strong increase in medullary TTP and MTT was observed, indicating a reduction in medullary blood flow velocity. In the cortex, a significant reduction in PI was found, probably because of a reduction in cortical blood volume. A faster recovery of both medullary and cortical PI in the group resuscitated with air could indicate that air might be more beneficial for renal perfusion than hyperoxia during resuscitation after renal hypoxia.