Psychiatry and clinical neurosciences
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Psychiatry Clin. Neurosci. · Aug 2007
T-helper 1/T-helper 2 cytokine imbalance and clinical phenotypes of acute-phase major depression.
Several studies have discussed the relationships between T-helper 1 (Th1) or Th2 cytokines and major depression. The aim of the present study was to investigate the relationships between Th1/Th2 cytokine balance and clinical phenotypes of acute-phase major depression. A total of 82 subjects including 42 patients with major depressive disorder and 40 healthy controls were recruited. ⋯ In addition, using ANCOVA with age and BMI adjustments, significantly higher serum IL-1beta level and IL-1beta/IL-10 ratio were noted in patients with melancholic features than patients with non-melancholic features. However, there were no significant differences in serum IL-1beta, TNF-alpha and IL-10 levels between patients with and without suicide attempt. In conclusion, serum TNF-alpha, IL-1beta level and IL-1beta/IL-10 ratio might play an important role in the psychopathology of acute-phase major depressive disorder.