Parkinsonism & related disorders
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Parkinsonism Relat. Disord. · Aug 2011
Gray matter volume deficits in spinocerebellar ataxia: an optimized voxel based morphometric study.
Spinocerebellar ataxias (SCA) are a group of autosomal dominant ataxias with varied clinical phenotypes. However there are no unique distinguishing features on routine neuroimaging among the various genetically defined SCAs. Voxel-based morphometry (VBM) provides an automated unbiased analysis of structural MRI scans and gives a comprehensive assessment of anatomical differences throughout the brain. ⋯ This study showed that the different subtypes of SCAs may have morphometric differences in the cerebellum, brainstem and the supratentorial structures.