Parkinsonism & related disorders
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Parkinsonism Relat. Disord. · Aug 2012
GPi and STN deep brain stimulation can suppress dyskinesia in Parkinson's disease.
To compare subthalamic nucleus (STN) to globus pallidus internus (GPi) deep brain stimulation (DBS) for control of motor fluctuations and for potential dyskinesia-suppressing qualities. ⋯ The overall clinical outcome of STN and GPi DBS for control of dyskinesia and motor fluctuations was similar. STN and GPi DBS both had some direct dyskinesia suppression effects.
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Parkinson's disease (PD) has been known as "the shaking palsy" as well as "paralysis agitans", yet clinically apparent weakness is not a feature of the disorder. Relative weakness, and early muscle fatigue may be demonstrated on testing but frank weakness should not be apparent on routine clinical examination. ⋯ Self perceived weakness was reported by 43.8%. Self perceived weakness was associated with fatigue but not with bradykinesia, tremor or total motor score (motor severity). SPW is common in PD but affects less than half the studied population. SPW appears to be related to fatigue, a major determinant of quality of life in PD, and therefore is an important symptom to understand.