Parkinsonism & related disorders
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Parkinsonism Relat. Disord. · Dec 2014
Randomized Controlled Trial Comparative StudyComparison of IPX066 with carbidopa-levodopa plus entacapone in advanced PD patients.
IPX066, an investigational extended-release carbidopa-levodopa (CD-LD) preparation, has demonstrated a rapid attainment and prolonged maintenance of therapeutic LD plasma concentrations in advanced Parkinson's disease (PD). This phase-3 crossover study assessed its efficacy and safety vs. CD-LD plus entacapone (CL + E). ⋯ In advanced PD, IPX066 showed improved efficacy, compared with CL + E, and appeared to be well tolerated.
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Parkinsonism Relat. Disord. · Dec 2014
Risk of Parkinson's disease following severe constipation: a nationwide population-based cohort study.
Constipation is a non-motor symptom of Parkinson's disease (PD). We investigated the association between the severity of constipation and subsequent risk of PD in a population-based sample. ⋯ Our study suggests that the severity of constipation is associated with a future diagnosis of PD in a dose-dependent manner.