Parkinsonism & related disorders
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Parkinsonism Relat. Disord. · Jun 2018
Cerebral gray matter volume losses in essential tremor: A case-control study using high resolution tissue probability maps.
Essential tremor (ET) is increasingly recognized as a multi-dimensional disorder with both motor and non-motor features. For this reason, imaging studies are more broadly examining regions outside the cerebellar motor loop. Reliable detection of cerebral gray matter (GM) atrophy requires optimized processing, adapted to high-resolution magnetic resonance imaging (MRI). We investigated cerebral GM volume loss in ET cases using automated segmentation of MRI T1-weighted images. ⋯ This study, which uses improved methodologies, provides evidence that GM volume loss in ET is present beyond the cerebellum, and in fact, is widespread throughout the cerebrum as well.
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Parkinsonism Relat. Disord. · Jun 2018
Case ReportsDCTN1 F52L mutation case of Perry syndrome with progressive supranuclear palsy-like tauopathy.
Perry syndrome is a rapidly progressive, autosomal dominant parkinsonism characterized by central hypoventilation, depression and severe weight loss. To date, eight DCTN1 mutations have been identified associated with Perry syndrome. A novel F52L DCTN1 mutation case of Perry syndrome is characterized by late-onset parkinsonism and frontotemporal atrophy. ⋯ In conjunction with long disease duration and aging, our findings suggest that the F52L DCTN1 mutation may evoke severe tauopathy and moderate α-synucleinopathy.
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Parkinsonism Relat. Disord. · Jun 2018
Pallidal dopaminergic denervation and rest tremor in early Parkinson's disease: PPMI cohort analysis.
s: Over recent years there have been some conflicting reports upon the role of pallidal dopaminergic denervation in rest tremor in Parkinson's disease. ⋯ Pallidal dopaminergic denervation appears unrelated to rest tremor severity in early Parkinson's disease.