Parkinsonism & related disorders
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Parkinsonism Relat. Disord. · Mar 2011
Acute effects of bilateral subthalamic stimulation on decision-making in Parkinson's disease.
Pathological gambling can develop in Parkinson's disease (PD), and impairment of decision-making may play an important role in the mechanism. To assess acute effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on decision-making, patients with PD who were eligible for STN-DBS were evaluated using the Iowa Gambling Task (IGT). ⋯ Bilateral STN-DBS may affect decision-making in acute post-operative stage.
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Parkinsonism Relat. Disord. · Jan 2011
The effect of levodopa dose and body weight on dyskinesia in a prevalent population of people with Parkinson's disease.
We aimed to investigate the effect of active dose and dose per kilogram (kg) of body weight of levodopa on the occurrence of dyskinesia within a prevalent population of people with PD. ⋯ Adjusting levodopa dose for body weight did not increase its degree of correlation with patient reported dyskinesia.
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Parkinsonism Relat. Disord. · Nov 2010
Review Historical ArticleParkinsonism and neurological manifestations of influenza throughout the 20th and 21st centuries.
Given the recent paper by Jang et al. on "A Highly Pathogenic H5N1 Influenza Virus" which reported a novel animal model of parkinsonism, we aimed to perform a complete historical review of the 20th and 21st century literature on parkinsonism and neurological manifestations of influenza. ⋯ To date there have been surprisingly few cases of neurological issues inclusive of parkinsonism associated with influenza pandemics. Given the recent animal model of H5N1 influenza associated parkinsonism, the medical establishment should be prepared to evaluate for the re-emergence of parkinsonism during future outbreaks.
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Parkinsonism Relat. Disord. · Nov 2010
Predictive factors affecting early deterioration of axial symptoms after subthalamic nucleus stimulation in Parkinson's disease.
Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment option for medically refractory Parkinson's disease (PD). However, some patients show deterioration of axial symptoms within a short time after surgery. ⋯ Multiple logistic regression analysis indicated that the significant independent variables related to early deterioration of axial symptoms were rapidly progressive short duration of the disease and advanced age at surgery. These results suggest that patients with rapidly progressing PD, who need early surgical intervention, tend to show early deterioration of axial symptoms after STN-DBS.