European journal of medical research
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We studied if injections of botulinum toxin into multiple pericranial muscles reduce pain of patients with tension-type headache. Nine patients with tension-type headache not sufficiently responding to physical therapy or to amitriptyline were studied. Patients kept a headache diary that was used to calculate the area under the headache curve (AUC) of 4 weeks before and after treatment. ⋯ No major side effects were reported by the patients. These results justify further studies of botulinum toxin therapy in patients with tension type headache. The presented scheme for injections of botulinum toxin into multiple pericranial muscles is a rational basis for the design of such studies.