European journal of medical research
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Clinical Trial Controlled Clinical Trial
Effects of a mistletoe preparation with defined lectin content on chronic hepatitis C: an individually controlled cohort study.
Despite advances in the therapy of chronic hepatitis C for some hepatitis C virus (HCV) genotypes interferon and ribavirin combination therapy is effective in less than 50% of patients. Abnobaviscum Quercus (AQ) is a mistletoe preparation containing defined amounts of mistletoe lectins (ML). It has shown immunomodulatory properties in vitro and in vivo. ⋯ A significant eosinophilia (p=0.0001) occurred between month 2 and 6 during treatment. 9 month treatment with a ML containing mistletoe preparation has no effect on viral load or ALT as markers of activity in patients with chronic hepatitis C. However, frequency and intensity of clinical signs and symptoms in our patients decreased significantly, similar to reports of improved quality of life in tumour patients treated with such preparations. A significant eosinophilia suggests that ML containing mistletoe preparations induce a T-helper 2 immune response.
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This research assessed the prevalence of cigarette smoking among Iranian medical students, resident physicians and attending physicians. ⋯ Of the participants 16.79% of males and 0.69% of females were smokers. Of the medical students, 18.48% of students, 12.5% of pre-externship students, 7.19% of externship students and 16.95% of internship students were smokers. Of resident physicians 11.11% were smokers. Among attending physicians 7.57% were smokers. The most common causes of current cigarette smoking were need (avoid withdrawal symptoms), pleasurable purposes and release of tension, respectively. Foreign filter tipped cigarette was the most common type of cigarette used. The mean of cigarette per day was 6.29 cigarettes and the mean age of starting cigarette was 19.71 years.