Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
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Randomized Controlled Trial
Efficacy and safety of topical nimesulide in the treatment of knee osteoarthritis.
Osteoarthritis (OA) affects mainly older people who are more sensitive to adverse effects of classic nonsteroidal anti-inflammatory drugs. Recent publications indicate that topically applied nonsteroidal anti-inflammatory drugs are effective and much safer than their oral analogues. ⋯ This study shows that topical nimesulide gel can have beneficial effects and can improve quality of life in patients with knee OA.