Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases
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Randomized Controlled Trial
Effects of lifestyle physical activity in adults with fibromyalgia: results at follow-up.
In a 12-week randomized controlled trial of the effects of lifestyle physical activity (LPA) on symptoms and function among adults with fibromyalgia, we found that LPA participants increased their average daily step count by 54%, improved their self-reported functioning by 18%, and reduced their pain by 35%. ⋯ Although participants reported greater perceived improvement at each assessment, the beneficial effects of LPA on physical activity, function, and pain found after the 12-week intervention were not sustained over time. This recidivism is seen in studies of activity and exercise in nearly any condition, and innovative methods that may prevent this are a focus of future studies.
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Case Reports
Colitis associated with active systemic lupus erythematosus successfully treated with rituximab.
Intestinal vasculitis is a serious and often underrecognized complication of systemic lupus erythematosus (SLE) usually managed with high-dose corticosteroids. We report a case of corticosteroid refractory colitis (likely due to intestinal vasculitis) that achieved remission with a single cycle of high-dose rituximab. This has not previously been described to our knowledge. ⋯ Six months later, she continued to be in remission with low-dose prednisolone. Intestinal vasculitis should be considered as a possible cause of acute abdominal pain in SLE as early recognition and treatment can improve long-term survival. Rituximab can be an effective alternative for patients refractory to conventional treatment.