Heart : official journal of the British Cardiac Society
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Randomized Controlled Trial Comparative Study Clinical Trial
Randomised double blind trial of oral versus intravenous flecainide for the cardioversion of acute atrial fibrillation.
To investigate whether an oral loading dose of flecainide is as safe and effective as intravenous flecainide for the cardioversion of acute atrial fibrillation. ⋯ Intravenous flecainide restored sinus rhythm more rapidly than oral flecainide, but at two hours and eight hours after treatment there was no difference in the proportion of patients cardioverted by the two approaches. These results suggest a role for oral loading doses of flecainide in the treatment of acute or symptomatic paroxysmal atrial fibrillation.