Annals of internal medicine
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Case Reports Multicenter Study Clinical Trial
Anticytoplasmic autoantibodies: their immunodiagnostic value in Wegener granulomatosis.
To determine disease specificity and sensitivity of anticytoplasmic autoantibodies (ACPA) for Wegener granulomatosis, as well as their value as a marker of disease activity. ⋯ Testing for ACPA in serum of patients with Wegener granulomatosis is valuable for differential diagnosis; furthermore, APCA can be used as a marker to follow disease activity. A new type of ELISA yielded the same results as indirect immunofluorescence for the specificity, sensitivity, and correlation with disease activity of ACPA.