Annals of internal medicine
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Meta Analysis
Meta-analysis: respiratory tolerance to regular beta2-agonist use in patients with asthma.
The regular administration of beta2-agonists may be associated with the development of tolerance to their effects. ⋯ Regular beta2-agonist use for at least 1 week in patients with asthma results in tolerance to the drug's bronchodilator and nonbronchodilator effects and may be associated with poorer disease control compared with placebo.