Annals of internal medicine
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Lymphangioleiomyomatosis (LAM) is a disorder that affects women and is characterized by cystic lung destruction, chylous effusions, lymphangioleiomyomas, and angiomyolipomas. It is caused by proliferation of abnormal smooth muscle-like cells. Sirolimus is a mammalian target of rapamycin inhibitor that has been reported to decrease the size of neoplastic growths in animal models of tuberous sclerosis complex and to reduce the size of angiomyolipomas and stabilize lung function in humans. ⋯ Intramural Research Program, National Heart, Lung, and Blood Institute, National Institutes of Health.
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Randomized Controlled Trial Comparative Study
Measuring blood pressure for decision making and quality reporting: where and how many measures?
The optimal setting and number of blood pressure (BP) measurements that should be used for clinical decision making and quality reporting are uncertain. ⋯ U.S. Department of Veterans Affairs Health Services Research and Development Service.
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Tuberous sclerosis complex (TSC) is associated with tumor development in the brain, retina, kidney, skin, heart, and lung. Seizures, intellectual disability, and characteristic skin lesions commonly manifest in early childhood, but some findings, notably renal angiomyolipomas and pulmonary lymphangioleiomyomatosis (LAM), emerge later, placing adults with undiagnosed TSC at increased risk for morbidity and mortality. ⋯ Intramural Research Program, National Institutes of Health, National Heart, Lung, and Blood Institute.