Annals of internal medicine
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Review Meta Analysis
Diagnostic Strategies for the Assessment of Suspected Stable Coronary Artery Disease : A Systematic Review and Meta-analysis.
There is uncertainty about which diagnostic strategy for detecting coronary artery disease (CAD) provides better outcomes. ⋯ None. (PROSPERO: CRD42022329635).
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Comment Randomized Controlled Trial Multicenter Study
Genotype-guided drug prescribing vs. usual care reduced clinically relevant adverse drug reactions at 12 wk.
Swen JJ, van der Wouden CH, Manson LE, et al; Ubiquitous Pharmacogenetics Consortium. A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study. Lancet. 2023;401:347-356. 36739136.
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The effectiveness of glucagon-like peptide-1 receptor agonists (GLP1RA) and sodium-glucose cotransporter-2 inhibitors (SGLT2i) in preventing major adverse cardiac events (MACE) is uncertain for those without preexisting cardiovascular disease. ⋯ VA Clinical Science Research and Development and supported in part by the Centers for Diabetes Translation Research.
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Gene therapy is a potential cure for sickle cell disease (SCD). Conventional cost-effectiveness analysis (CEA) does not capture the effects of treatments on disparities in SCD, but distributional CEA (DCEA) uses equity weights to incorporate these considerations. ⋯ Yale Bernard G. Forget Scholars Program and Bunker Endowment.