Annals of internal medicine
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Comment Randomized Controlled Trial
In higher-risk, statin-intolerant adults with diabetes, bempedoic acid reduced MACE at a median 3 y.
Ray KK, Nicholls SJ, Li N, et al; CLEAR OUTCOMES Committees and Investigators. Efficacy and safety of bempedoic acid among patients with and without diabetes: prespecified analysis of the CLEAR Outcomes randomised trial. Lancet Diabetes Endocrinol. 2024;12:19-28. 38061370.
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Meta Analysis
In solid tumors, neoadjuvant or adjuvant immune checkpoint blockade increases treatment-related grade 3 or 4 adverse events.
Fujiwara Y, Horita N, Adib E, et al. Treatment-related adverse events, including fatal toxicities, in patients with solid tumours receiving neoadjuvant and adjuvant immune checkpoint blockade: a systematic review and meta-analysis of randomised controlled trials. Lancet Oncol. 2024;25:62-75. 38012893.
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Meta Analysis
Low-dose ketamine safely reduces acute pain in the ED with a more rapid and shorter effect than morphine.
Guo J, Zhao F, Bian J, et al. Low-dose ketamine versus morphine in the treatment of acute pain in the emergency department: a meta-analysis of 15 randomized controlled trials. Am J Emerg Med. 2024;76:140-149. 38071883.
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There is increasing concern for the potential impact of health care algorithms on racial and ethnic disparities. ⋯ Agency for Healthcare Quality and Research.