Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
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Randomized Controlled Trial Multicenter Study
Prevention of postoperative venous thromboembolism in Japanese patients undergoing total hip or knee arthroplasty: two randomized, double-blind, placebo-controlled studies with three dosage regimens of enoxaparin.
Enoxaparin is a low-molecular-weight heparin indicated in Europe and North America for the prevention of venous thromboembolism (VTE) in patients undergoing major orthopedic surgery. Registration trials of enoxaparin have been conducted primarily in Caucasian populations, and the efficacy and safety of enoxaparin in Japanese patients have not been demonstrated. We evaluated three dosage regimens of postoperative enoxaparin in Japanese patients undergoing elective total hip or knee arthroplasty. ⋯ Our findings support the use of enoxaparin (20 mg bid daily, commencing 24-36 h postoperatively) in Japanese patients undergoing total hip or knee arthroplasty.