Journal of managed care pharmacy : JMCP
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New cytotoxic agents and regimens, as well as immunotherapeutics, have recently been introduced for treatment of colorectal cancer (CRC). ⋯ The health care cost of CRC treatment is increasing significantly over time, which is most likely caused by the use of new regimens, higher chances of surgery and radiation, and occurrence of various comorbidities and metastatic diseases due to increasing survival time.
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Schizophrenia is a chronic, debilitating disease that affects approximately 1% of the U.S. population and has disproportionately high costs. Several factors, including age, gender, insurance status, and comorbid conditions, have been hypothesized to be associated with schizophrenia- related costs. ⋯ Identification of factors associated with a high-cost population may help decision makers in managed care, government, and other organizations allocate resources more efficiently and health care providers manage patients more effectively through assignment of these patients to case managers and appropriate monitoring and treatment.
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Comparative Study Observational Study
Antiviral regimen complexity index as an independent predictor of sustained virologic response in patients with chronic hepatitis C.
Hepatitis C virus (HCV) infection affects more than 170 million people worldwide, and one-third of them have human immunodeficiency virus (HIV) coinfection. Multiple studies have been conducted in order to identify the factors that may explain different responses to treatment among patients. However, the reasons why HIV-HCV coinfected patients have lower responses to treatment are not clear. In addition, no studies have evaluated the influence of the complexity of the therapeutic regimen for hepatitis C infection on clinical outcomes. ⋯ The medication regimen complexity may be a crucial factor to achieve therapeutic success when treating patients for hepatitis C. The adaptation of this index in patients with HCV provides an objective value of the antiviral regimen complexity and could help us to identify patients in clinical practice who require multidisciplinary attention. Simplification of the antiretroviral regimen might result in a greater response to treatment for hepatitis C.