Annals of surgery
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Randomized Controlled Trial
Skeletal muscle is anabolically unresponsive to an amino acid infusion in pediatric burn patients 6 months postinjury.
To evaluate leg muscle, whole-body muscle, and whole-body nonmuscle protein response to anabolic signaling of amino acids in pediatric burn patients at 6 months after injury. ⋯ In pediatric burn patients at 6 months postinjury, leg muscle protein net deposition is unresponsive to amino acid infusion; and whole-body protein breakdown is significantly higher than in the control group.
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Randomized Controlled Trial Multicenter Study Comparative Study
Out-of-hospital hypertonic resuscitation after traumatic hypovolemic shock: a randomized, placebo controlled trial.
To determine whether out-of-hospital administration of hypertonic fluids would improve survival after severe injury with hemorrhagic shock. ⋯ Clinical Trials.gov, NCT00316017.
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Review Comparative Study
Update on the comparative safety of colloids: a systematic review of clinical studies.
To provide an updated systematic review on the comparative safety of colloids based on recent clinical studies. ⋯ Albumin displayed a more favorable safety profile than HES. Available evidence does not support the existence of consistent safety differences between HES solutions.
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Clarify the incidence of thyroid cancer in patients with Familial adenomatous polyposis (FAP) in a prospective study of thyroid neck US screening. ⋯ The incidence of thyroid cancer among FAP patients is high. Medical history and exam are inadequate to identify patients with thyroid cancer, thus thyroid screening with US is warranted.