Annals of surgery
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To test the effects of enhanced intracellular oxygen contents on the metastatic potential of colon cancer. ⋯ Restoring oxygen in metastatic colon cancer through ITPP inhibits tumor spread and markedly improves animal survival; an effect that is enhanced through the application of subsequent chemotherapy. These promising novel findings call for a clinical trial on ITPP in patients with colorectal cancer, which is under way.