Annals of surgery
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Multicenter Study Comparative Study
Safety of Overlapping Surgery at a High-volume Referral Center.
To compare safety profiles of overlapping and nonoverlapping surgical procedures at a large tertiary-referral center where overlapping surgery is performed. ⋯ These findings from administrative and clinical registries support the safety of overlapping surgical procedures at this center but may not extrapolate to other centers.
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We sought to assess whether pharmacological inhibition of hypoxia-inducible transcription factor (HIF)-prolyl hydroxylase enzymes (PHD1, PHD2, and PHD3) is a suitable strategy to stimulate liver regeneration after partial hepatectomy for colorectal liver metastases (CRLM). ⋯ Pharmacological inhibition of PHDs using EDHB might represent a novel and safe strategy in the treatment of multiple bilobar CRLM.