Annals of surgery
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Randomized Controlled Trial
A Health Economic Evaluation of the World Health Organization Surgical Safety Checklist: A Single Center Assessment.
To evaluate cost-effectiveness of the WHO Surgical Safety Checklist. ⋯ Implementation of the WHO checklist was a cost-effective strategy for improving surgical safety.
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Meta Analysis
Biomarkers for the Early Diagnosis of Sepsis in Burns: Systematic Review and Meta-analysis.
The aim of this study was to evaluate the diagnostic performance of all biomarkers studied to date for the early diagnosis of sepsis in hospitalized patients with burns. ⋯ The most widely studied biomarkers are poorly predictive for sepsis in burns patients. Brain natriuretic peptide, stroke volume index, TNF-alpha, and cell-free DNA showed promise in single studies and should be further evaluated. A standardized approach to the evaluation of diagnostic markers (including time of sampling, cut-offs, and outcomes) would be useful.
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Multicenter Study
Ten-year Evaluation of a Large Retrospective Cohort Treated by Sacral Nerve Modulation for Fecal Incontinence: Results of a French Multicenter Study.
The aim of this study was to assess the effectiveness of sacral nerve modulation (SNM) in a large cohort of patients implanted for at least 10 years, quantify adverse event rates, and identify predictive factors of long-term success. ⋯ Long-term efficacy was maintained in approximately half of the FI patients treated by SNM at least 10 years post-implantation.
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To compare outcome after noncardiac surgery between HF patients with reduced versus preserved ejection fraction. ⋯ HFrEF patients have increased risks of noncardiopulmonary complications, mortality, and readmission after noncardiac surgery. These findings suggest that targeted perioperative care for HF subtypes may be crucial for the growing population of HF patients undergoing noncardiac surgery. Despite cardiopulmonary complications not being statistically different between HF subtypes, given the high occurrence rate, any intervention to decrease the rate would be clinically meaningful.
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The primary objective of this study was to identify novel genes that predispose people in the Japanese population to FPC. ⋯ Our findings indicate that FPC patients harbor potentially deleterious causative germline variants in tumor suppressor genes, which are known to acquire somatic mutations in pancreatic cancer, and that somatic loss of heterozygosity of some FPC susceptibility genes may contribute to the development of FPC in the absence of somatic KRAS-activating mutation. Genetic testing for a wider variety of FPC-predisposition genes could provide better screening approach for high-risk groups of pancreatic cancer.