Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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J Coll Physicians Surg Pak · Jan 2023
Case ReportsTransfusion-associated Graft versus Host Disease: A Certain but Avoidable Cause of Death.
Transfusion-associated graft versus host disease (TA-GvHD) is a rare complication of blood transfusion. It is a delayed transfusion reaction that usually presents from day 7 to day 14 following a transfusion. It can affect both immunocompromised as well as immunocompetent patients. ⋯ The condition is usually fatal in 90% of cases. Here, we present one such case in which the maternal blood transfused to an infant cost him his life within 12 days of transfusion. Key Words: Transfusion, Homozygous antigen, Heterozygous antigen, Graft versus host disease.
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J Coll Physicians Surg Pak · Jan 2023
Case ReportsBombay Blood Group: An Incidental Discovery in a Family.
Bombay phenotype is an uncommon blood type. It is found in approximately 1 in 10,000 people in the Indian subcontinent and approximately 1 in 1,000,000 in Europe. ⋯ Herein, we report an incidental discovery of a family with three members having Bombay phenotype on routine antenatal examination. Key Words: ABO blood group system, Bombay phenotype, Cross matching.
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J Coll Physicians Surg Pak · Jan 2023
Case ReportsMalignant Phyllodes Tumour with Osteoclast-type Giant Cells in Young Females: A Rare Histology and Differential Diagnoses.
Phyllodes tumour (PT) is a biphasic fibroepithelial tumour of the breast that accounts for 0.3-1% of all primary breast neoplasms. It is subdivided into benign, borderline, and malignant categories based on histologic features including stromal overgrowth, stromal hypercellularity, mitotic count, degree of atypia, and type of margins. Malignant PT (MPT) is characterised by infiltrative margins, marked stromal overgrowth, increased stromal hypercellularity, greater than 10 mitoses/10 high-power fields (HPFs), and moderate to severe atypia. ⋯ We herein report cases of MPT with OGCs in two young females who had a history of swelling in unilateral breast for two-three years. Histologic examination revealed classic phyllodes areas admixed with a sarcomatous stromal component with OGCs. Key Words: Malignant phyllodes tumour, Breast, Osteoclast-type giant cells.