Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
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J Coll Physicians Surg Pak · Dec 2024
Meta AnalysisAssociation Between Neuropsychiatric Event and Systemic Lupus Erythematosus Clinical Manifestation: A Meta-Analysis.
To uncover the clinical characteristics and investigate the underlying causes of psychiatric manifestations in patients with systemic lupus erythematosus (SLE), including its subset, neuropsychiatric systemic lupus erythematosus (NPSLE). Through comprehensive database searches in PubMed, Embase, Medline, and Cochrane, from their inception to August 2023, the study focused on adult SLE and NPSLE cases. From the selected studies, data were synthesised via a random-effects meta-analysis, encompassing a total of 2,997 subjects across six studies. ⋯ The analysis suggests that the causality behind these manifestations is multifactorial, encompassing mental state, autoantibody profiles, and environmental factors, thus providing valuable insights into the clinical management and understanding of SLE and NPSLE. This study emphasises the complexity of SLE, particularly in its neuropsychiatric manifestations, and underscores the importance of targeted treatment strategies. Key Words: Systemic lupus erythematosus, Neuropsychiatric systemic lupus erythematosus, Neuropsychiatric event, Meta-analysis.
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J Coll Physicians Surg Pak · Dec 2024
Meta AnalysisThymosin Alpha 1 Plus Routine Treatment for the Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.
This systematic review was conducted to assess the curative effect of Thymosin alpha 1 in the acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients. Six electronic databases including EMBASE, PubMed, Cochrane Library, China National Knowledge Infrastructure Database, Chinese Biomedical Database, and Wanfang Database were searched for eligible papers focusing on the thymosin alpha 1 treatment in AECOPD patients. The effectiveness outcomes included T cell subset, pulmonary function, arterial blood gases, and the length of hospital stay. ⋯ Thymosin alpha 1 could significantly boost the immune function, and improve pulmonary function and arterial blood gas of AECOPD patients than routine treatment only. More high-quality randomised controlled trials are needed to further confirm Thymosin alpha 1 efficacy. Key Words: Thymosin alpha 1, Efficacy, Acute exacerbation of chronic obstructive pulmonary disease, Meta-analysis.
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J Coll Physicians Surg Pak · Dec 2024
Randomized Controlled TrialEffect of Blood Component Transfusion on Coagulation Function in Postpartum Haemorrhage.
Postpartum haemorrhage (PPH) is a serious complication of pregnancy. In this study, patients with PPH were treated with blood component transfusion, and the effectiveness of blood component transfusion and its influence on coagulation function were analysed. This retrospective randomised controlled study evaluated the clinical data of patients with PPH who were admitted to the Department of Blood Transfusion at the First Affiliated Hospital of Xiamen University, from January 2021 to December 2021. ⋯ The combination of RBC, plasma, and cryoprecipitate in a reasonable proportion effectively improves coagulation function in haemorrhage puerperae, showing a good clinical treatment effect. It is worth promoting. Key Words: Postpartum, Blood component transfusion, Coagulation, Resuscitation rate.
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J Coll Physicians Surg Pak · Dec 2024
Comparative Study Observational StudyComparison of Intrathecal Morphine versus Ultrasound-Guided Regional Analgaesia Techniques for Post-Caesarean Recovery Quality.
To investigate the impact of ultrasound-guided regional analgaesia techniques on postoperative recovery and compare them with those of intratecal morphine (ITM) in obstetric patients undergoing elective caesarean delivery (CD). ⋯ Caesarean delivery, Multimodal analgaesia, Patient-reported outcome, Regional analgaesia techniques, Quality of recovery.
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J Coll Physicians Surg Pak · Dec 2024
Observational StudyQuality of Life, Perceived Stigma, and Challenges Faced by the Parents of Girls with Congenital Adrenal Hyperplasia.
To assess the quality of life (QoL), perceived stigma, and extent of anxiety and/or depression among parents of female children with congenital adrenal hyperplasia (CAH). ⋯ Parental anxiety, Congenital adrenal hyperplasia, Disorders of sex development, Gender assignment, Gender.