Annals of the rheumatic diseases
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Randomized Controlled Trial Multicenter Study Comparative Study
A prospective randomised multicentre study comparing continuous and intermittent treatment with celecoxib in patients with osteoarthritis of the knee or hip.
To compare the effects of continuous and intermittent celecoxib treatment in patients with knee or hip osteoarthritis in flare. ⋯ The results of this pilot study indicate a potential clinical difference between continuous and intermittent treatment with celecoxib, and may be useful in designing future trials. A larger trial on both efficacy and safety outcomes is required for conclusive evidence in favour of either continuous or intermittent treatment.