Annals of the rheumatic diseases
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Randomized Controlled Trial Multicenter Study
Corticosteroid injections effective for trigger finger in adults in general practice: a double-blinded randomised placebo controlled trial.
To study efficacy and safety of corticosteroid injections for trigger finger (flexor tenosynovitis) in adults in general practice. ⋯ Local injection with TCA is effective and safe for treating trigger finger as compared to placebo injection. The effects of steroid injections last up to 12 months.
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To study the clinical outcome, treatment response, T-cell subsets and functional consequences of a novel tumour necrosis factor (TNF) receptor type 1 (TNFRSF1A) mutation affecting the receptor cleavage site. ⋯ The TNFRSF1A V173D cleavage site mutation may be associated with an increased risk for cardiovascular complications and shows a strong response to etanercept. T-cell senescence does not seem to have a pathogenetic role in affected patients.