Annals of the rheumatic diseases
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Comparative Study
The -670G>A polymorphism in the FAS gene promoter region influences the susceptibility to systemic sclerosis.
To evaluate the role of the single-nucleotide polymorphism (SNP) at position -670 in the FAS gene promoter (FAS-670G>A) in influencing the susceptibility, clinical features and severity of systemic sclerosis (SSc). ⋯ The FAS-670A allele is significantly associated with susceptibility to SSc, suggesting a role for a genetic control of apoptosis in the pathogenesis of the disease.