Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
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Case Reports
Difficulties in diagnosing and managing coexisting primary hypothyroidism and resistance to thyroid hormone.
To report a case of resistance to thyroid hormone compounded by autoimmune primary hypothyroidism and to discuss the unusual pattern of results of thyroid function tests. ⋯ This patient has an interesting combination of autoimmune primary hypothyroidism and resistance to thyroid hormone. Levothyroxine replacement therapy was complicated by the nonspecificity of symptoms and the lack of an established TSH target value in this condition. Consideration should be given to using the affected family members' mean TSH level, when available, as a target guide for replacement therapy.